The suspects, who are believed to be armed and dangerous, entered the residence in the 7400 block of El Manor Avenue around 9:30 p.m. Wednesday.
Once inside the home, they forced the homeowners to open their safe, then tied up both victims and pistol-whipped the husband.
He was hospitalized, but details regarding his condition were not immediately available.
The suspects, who were both wearing orange vests, left with the safe in what was described as a white Chevy Malibu.
Southern California Gas Company is warning customers to verify an employee's identification before letting anyone into your home.
Anyone who may have information about these suspects is asked to contact LAPD Pacific Division Detectives at: 310-482-6313.